Gut microbiome alters functions of mutant p53 to promote tumorigenesis
نویسندگان
چکیده
منابع مشابه
The Gut Microbiome Modulates Colon Tumorigenesis
UNLABELLED Recent studies have shown that individuals with colorectal cancer have an altered gut microbiome compared to healthy controls. It remains unclear whether these differences are a response to tumorigenesis or actively drive tumorigenesis. To determine the role of the gut microbiome in the development of colorectal cancer, we characterized the gut microbiome in a murine model of inflamm...
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The tumour suppressor p53 is frequently mutated in tumours. Mutant p53 (Mutp53) proteins often gain new activities in promoting tumorigenesis, defined as gain-of-function (GOF). Mutp53 can accumulate to high levels in tumours, which promotes mutp53 GOF in tumorigenesis. The mechanism of mutp53 accumulation is poorly understood. Here we find that MDM2 isoforms promote mutp53 accumulation in tumo...
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ژورنال
عنوان ژورنال: Signal Transduction and Targeted Therapy
سال: 2020
ISSN: 2059-3635
DOI: 10.1038/s41392-020-00336-y